ABSTRACT
PURPOSE: The purpose of this study was to evaluate the biodegradation and biocompatibility of poly L-lactic acid (PLLA) implantable mesh under in vitro and in vivo conditions. METHODS: PLLA mesh was examined for changes in weight and tensile strength. The histology of the tissue around the PLLA implant was also evaluated. RESULTS: The weight and tensile strength of the PLLA prosthesis was stable for 180 days. In addition, the surface of the PLLA mesh was not digested under in vitro or in vivo conditions as determined by scanning electron microscope. Histologically, there were no significant changes in the diameters of implanted PLLA mesh and subtype fibers over the course of 180 days. Likewise, there were no significant changes in the number of inflammatory and mast cells after 180 days, nor was there an increase in the percentage of collagen surrounding the PLLA mesh. CONCLUSIONS: The results indicate that PLLA prostheses have good rigidity and biocompatibility in vivo and in vitro.
Subject(s)
Collagen , In Vitro Techniques , Lactic Acid , Mast Cells , Prostheses and Implants , Tensile StrengthABSTRACT
Pneumococcus is a very important pathogen for children and elderly people, and causes considerable morbidity and mortality in these groups. Pneumococcal vaccination is relatively safe, and is being increasingly used for the prevention of pneumococcal disease, such as meningitis, pneumonia, otitis media, and bacteremia. Mild adverse reactions of pneumococcal vaccination are relatively common, and include erythema, pain, fever, myalgia, and headaches. However, adverse skin reactions are very rare. Here, we present a case of pneumococcal vaccination-induced localized toxic reaction mimicking fixed drug eruption on a nearby vaccination injection site in an infant, which has not previously been documented in Korea.
Subject(s)
Aged , Child , Humans , Infant , Bacteremia , Drug Eruptions , Erythema , Fever , Headache , Korea , Meningitis , Mortality , Myalgia , Otitis Media , Pneumonia , Skin , Streptococcus pneumoniae , VaccinationABSTRACT
Glufosinate ammonium herbicide is a nonselective herbicide used worldwide because it is less toxic than paraquat. Acute glufosinate ammonium intoxications manifest as injuries of the intestinal mucosa, abdominal pain, vomiting, diarrhea, convulsions, respiratory distress, and death resulting from human abuse. We present a case of irritant contact dermatitis on the back caused by accidental exposure to glufosinate ammonium and followed by erythema multiforme-like eruptions without systemic intoxication, which has not been documented previously in Korea.
Subject(s)
Humans , Abdominal Pain , Ammonium Compounds , Dermatitis, Contact , Diarrhea , Erythema Multiforme , Erythema , Intestinal Mucosa , Korea , Paraquat , Seizures , VomitingABSTRACT
BACKGROUND: UVB irradiation induces apoptosis or/and autophagy through several molecular pathways in keratinocytes. However, the precise molecular mechanism of UVB-induced autophagy is largely unknown in keratinocytes. OBJECTIVE: The purpose of this study was to investigate the molecular mechanisms of UVB-induced apoptosis and autophagy in HaCaT cell lines. METHODS: Cells were irradiated by UVB (Westinghouse FS-40 sunlamps) with various doses (0, 30, 60, 120, 240 mJ/cm2). The expression levels of caspase-3, Bax, Bcl2, Bcl-X(L) and LC3 were confirmed by Western blot analysis in UVB-irradiated HaCaT cell lines. Apoptotic cells were analyzed by PI staining, and autophagy cells were analyzed by immunofluorescent staining. RESULTS: The expression of Bcl-X(L) decreased from UVB 60 mJ/cm2 and Bcl2 decreased from UVB 240 mJ/cm2. The expression of caspase-3 was increased from UVB 120 mJ/cm2. These data showed that UVB-induced apoptosis is mediated by up-regulation of caspase-3 and down-regulation of Bcl2 and Bcl-X(L). Furthermore, the expression of LC3 increased from UVB 120 mJ/cm2. In addition, autophagy formation was observed in few fractions of apoptotic HaCaT cells in immunofluorescent staining; most apoptotic cells did not show autophagy formation. Moreover, autophagy formation inhibitor treatment induced a slight increment of apoptotic cell population under UVB irradiation. CONCLUSION: UVB irradiation induces not only apoptotic cell death but also autophagy formations; these events may create a defense mechanism for the prevention of apoptosis in UVB-treated HaCaT cells.
Subject(s)
Apoptosis , Autophagy , Blotting, Western , Caspase 3 , Cell Death , Cell Line , Down-Regulation , Keratinocytes , Up-RegulationABSTRACT
Stevens-Johnson syndrome (SJS) is a rare, severe and immune-mediated cutaneous reaction usually secondary to the idiosyncratic reaction of medication, such as sulfonamide, anti-convulsant, NSAIDs and so on. The infection with Mycoplasma pneumoniae is also a well-documented cause. Influenza vaccination is relatively safe and increases with pandemic advance. Mild adverse reactions of influenza vaccination are relatively frequent, such as erythema, pains, fevers, myalgia, headaches and so on. But, severe skin adverse reactions are also very rare. We present a case of seasonal influenza vaccination induced Stevens-Johnson syndrome which has not previously been documented in Korea.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal , Erythema , Fever , Headache , Influenza, Human , Korea , Mycoplasma pneumoniae , Pandemics , Pneumonia, Mycoplasma , Seasons , Skin , Stevens-Johnson Syndrome , VaccinationABSTRACT
Halo nevus is a pigmented nevus surrounded by acquired round depigmentation. Depigmentation appears mostly around several types of pigmented lesions, such as acquired nevus, congenital nevus, blue nevus and Spitz nevus. In contrast, it is rare that depigmentation develops around a congenital nevus. While the precise etiology of halo nevus and vitiligo remains uncertain, several theories suggest that both phenomena result from an immunologic reaction to melanocytes by CD8 + T cell. We report a case of halo congenital nevus in the arm, which is followed by periocular vitiligo. This is the third case in Korean dermatological literature.
Subject(s)
Arm , Melanocytes , Nevus , Nevus, Blue , Nevus, Epithelioid and Spindle Cell , Nevus, Halo , Nevus, Pigmented , VitiligoABSTRACT
Recently, Stevens-Johnson syndrome associated with methazolamide has been reported in Koreans, more frequently. Methazolamide is a carbonic anhydrase inhibitor commonly used for lowering intraocular pressure in glaucoma and other ophthalmologic diseases. We reported five cases of Stevens-Johnson syndrome induced by methazolamide. All patients showed atypical clinical manifestations, compared to classical Stevens-Johnson syndrome. Methazolamide induced Stevens-Johnson syndrome showed scattered or confluent maculopapular eruptions initially, which are similar to morbiliform drug eruption with mild lip erosion and palmar erythema. Even though there was no skin erosion initially, it showed rapid progression to severe erosion on the trunk and palmoplantar erythema within 5 to 7 days. Therefore, our data indicated that methazolamide induced Stevens-Johnson syndrome should be checked for a patient who has a history of ophthalmologic treatment with a drug eruption like skin lesion.
Subject(s)
Humans , Carbonic Anhydrases , Drug Eruptions , Erythema , Glaucoma , Intraocular Pressure , Lip , Methazolamide , Skin , Stevens-Johnson SyndromeABSTRACT
Reactive perforating collagenosis (RPC) is one of a range of essential perforating disorders. Two types have been recognized: the childhood or inherited form, and the adult or acquired form. Acquired RPC is usually associated with systemic disease, especially diabetes mellitus and/or renal failure. Lesions of acquired perforating collagenosis are usually smaller than 1 cm, but lesions of the giant variant of acquired perforating collagenosis are larger than 2 cm. We present a case of the giant variant of acquired perforating collagenosis, which has not previously been documented in Korea.